PLASMA CORTISOL-LINKED GENE NETWORKS IN HEPATIC AND ADIPOSE TISSUES IMPLICATE CORTICOSTEROID-BINDING GLOBULIN IN MODULATING TISSUE GLUCOCORTICOID ACTION AND CARDIOVASCULAR RISK

Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

Genome-wide association meta-analysis (GWAMA) by the Cortisol Network (CORNET) consortium identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with morning plasma cortisol, cardiovascular disease (CVD), and SERPINA6 mRNA expression encoding corticosteroid-binding globulin (CBG) in the liver.These and other fi

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Tectono-structural framework of the Indo-Myanmar Ranges: Implications for the structural development on the geology of the Rakhine Coastal Region, Myanmar

The Indo-Myanmar Ranges (IMR), known as an accretionary prism, lies between the Kaladan Fault (subduction suture) in the west and Kabaw Fault (the boundary between flysch units and molasse units) Energy Bars in the east is very important to interpret the paleogeographic evolution of the major continents, restoring the paleogeography and plate bound

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Calcium Increase and Substance P Release Induced by the Neurotoxin Brevetoxin-1 in Sensory Neurons: Involvement of PAR2 Activation through Both Cathepsin S and Canonical Signaling

Red tides involving Karenia brevis expose humans to brevetoxins (PbTxs).Oral exposition triggers neurotoxic shellfish poisoning, whereas inhalation induces a respiratory syndrome and sensory disturbances.No curative treatment is available and the pathophysiology is not fully elucidated.Protease-activated receptor 2 (PAR2), cathepsin S (Cat-S) and s

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